10 Benefits of Grape Seed Extract, Based on Science
- Dietitian.Lauren Hmede
- Nov 13, 2019
- 2 min read
Grape seed extract (GSE) is a dietary supplement made from the seeds of grapes.
It’s a potent source of antioxidants, particularly proanthocyanidins.
The antioxidants in GSE may help alleviate the oxidative stress, inflammation, and tissue damage that can occur alongside chronic diseases.
Note that grape seed extract and grapefruit seed extract are both marketed as supplements and abbreviated by the acronym GSE. This article discusses grape seed extract.
Here are 10 health benefits of grape seed extract, all based on science.
1. Can reduce blood pressure
GSE may help reduce blood pressure, particularly in young to middle-aged people and those who have excess weight.
2. Can improve blood flow
GSE has been shown to improve blood flow and reduce the risk of blood clotting, which may benefit those with circulatory problems.
3. Could reduce oxidative damage
GSE may help reduce your risk of heart disease by inhibiting the oxidation of LDL (bad) cholesterol and reducing oxidation to heart tissue during times of stress.
4. May improve collagen levels and bone strength
Animal studies show promising results regarding GSE’s ability to help treat arthritic conditions and promote collagen health. However, human-based research is lacking.
5. Supports your brain as it ages
GSE shows potential to inhibit many of the degenerative characteristics of brain and cognitive decline. However, more human studies are needed.
6. Can improve kidney function
GSE may offer protection against damage from oxidative stress and inflammation, thus promoting kidney health.
7. Can inhibit infectious growth
GSE may inhibit a variety of microbes and offer protection against antibiotic-resistant bacterial strains, foodborne bacterial illnesses, and fungal infections like candida.
8. May reduce cancer risk
GSE also appears to reduce chemotherapy-induced toxicity in animal studies without negatively affecting treatment. More human-based research is needed.
9. May protect your liver
GSE appears to protect your liver against drug-induced toxicity and damage. However, more human studies are needed.
10. Enhances wound healing and appearance
GSE creams appear to increase growth factors in your skin. As such, they may aid wound healing and help reduce the signs of skin aging.
Possible side effects
GSE appears to be well tolerated. However, pregnant and breastfeeding women should avoid it. Also, those taking certain medications should discuss taking this supplement with their healthcare provider.

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